Deloxan^® Metal Scavengers

The use of either heterogeneous or homogeneous catalysts can result in soluble metal contamination. These soluble metals can be detrimental to product quality and product yield. In the case of active pharmaceutical ingredient (API) development, the metal catalyst must be removed to a regulated level.

Types of metal contamination:

• Almost all transition metals used in chemical synthesis 
• Frequently used transition metals: Pd, Pt, Rh, Ru, Ir, Zn and Cu
• Metals in oxidised, zero-valent or colloidal form  

Deloxan^® Metal Scavengers are macroporous organofunctional polysiloxane beads with properties that make them ideal for removing contaminative soluble metals.

Deloxan^® Metal Scavengers offer an effective solution to many problems related to transition metal removal and precious metal recovery.

Benefits of our Deloxan^® Metal Scavengers:

• They save you time and effort in removing transition metals from APIs or intermediates by avoiding chromatography or crystallisation. 
• The scavenger is easy to handle: you can quickly filter it off and it leaves no residuals in your product.
• You can easily switch the mode of operation, as the scavengers can be used both in batch and continuous modes.  
• The scavengers can be readily applied: Deloxan^® works in all solvents and up to 250°C.

Our Products

Deloxan^® THP II with thiourea functionality
Deloxan^® MP with thiol functionality

Both are available in fine grade (0.1–0.3mm) or coarse grade (0.3–1.4mm).

Organofunctional polysiloxanes overcome the drawbacks of organic polymers by virtue of their inert matrix material and their compatibility with solvents. Furthermore, the surface density of the functional groups that are responsible for the scavenging effect is significantly higher in Deloxan^® Metal Scavengers than in surface-modified or post-reacted polymers.

Product features:

• Excellent metal scavenging properties for Pd, Pt, Rh, Ag, Au, Zn, Cu(I), Cd, Hg and Pb
• Good metal scavenging properties for Ru, Ir, Cu(II) and Fe(III)
• High structural stability – no swelling or shrinking
• High attrition resistance, durability and low friability
• Compatible with all solvents
• High thermal stability
• No electric charging if used in wet form
• Well-defined pore size structure
• Applicable in slurry and fixed bed modes
• Excellent filtration behaviour due to large particle size
• High specific surface area
• Stable in a wide pH range
• Can be refined and metals recovered
• Commercially available in large quantities